格林巴利综合征和相关周围神经病.pptVIP

任 980-1985年上 1987-1990学,医学硕士 ,医学博士 历任社会职务 中华医学会神经病学分会神经心理与行为神经病组委员 中华医学会神经病学分会痴呆与认知障碍组委员 中华医学会老年病病学分会老年神经病学组委员 上海医学会神经病学分会委员 中华医学会上海分会老年病学专科委员会委员 中国老年保健医学研究会老年认知心理疾病分会委员 中国医师协会疼痛医师专委会委 中国医师协会神经病学分会神经心理与情绪障碍专委会副主任委 研究与工作方向 痴杲与认知障碍临床与研 遗传性与自身免疫性周围神经病临床与研究 临床神经心理学与大脑半球机能不对称性研究  ak Guillain-Barre  Introduction Guillain barre综合征的特点是四肢对称性 paresthesias generalized weakness  Pathogenesis of GBS not yet fully understood and thinking is GBS may not be a single disease but a variety of acute neuropathies  Pathogenesis of GBS not yet fully understood and thinking is with a number of related immune-mediated pathogenetic mechanisms A. Most common immunopathologic finding a. endoneurial inflammation in 0 spinal nerves roots b) distal nerve segments, c) or around potential nerve entrapment sites.  Pathogenesis of GBS not yet fully understood and thinking is with a number of related immune-mediated pathogenetic mechanisms B. Target antigens appear to be common to a. the axon b. myelin sheath or both a) antigens, mechanism of injury somewhat unclear.  病因 GBS是一种自身免疫性疾病 病人在发病前有感染史, 包括EB病毒,巨细胞病毒,支原体,弯曲杆菌等 GBS是一个脱髓鞘的过程 近年发现,空肠弯曲杆菌或荆疾之后的GB能表现为轴突变性型 有时,外科手术急剧的诱发因子  脱髓鞘 NERF ENDOMMA  脱髓鞘 Normal nerve Exposed fib Damaged myelin @Mayo Foundation for Med ical Education and Research. All rights reserv