神经精神药理英文课件：ANTIEPILEPTIC DRUGS.pptVIP

TOPIRAMATE (Topamax) Rapidly absorbed, bioav. is 80%, has no active metabolites, excreted in urine.T1/2 = 20-30 hrs Blocks repetitive firing of cultured neurons, thus its mechanism may involve blocking of voltage-dependent sodium channels Potentiates inhibitory effects of GABA (acting at a site different from BDZs and BARBs). Depresses excitatory action of kainate on AMPA receptors. Teratogenic in animal models. Toxicity: Somnolence Fatigue Dizziness Cognitive slowing Paresthesias Nervousness Confusion Urolithiasis(尿结石) Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug.