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Pd催化的偶合反应综述.pdf

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Review /acscatalysis Development of Preformed Pd Catalysts for Cross-Coupling Reactions, Beyond the 2010 Nobel Prize Hongbo Li,† Carin C. C. Johansson Seechurn,‡ and Thomas J. Colacot†, * † Johnson Matthey Catalysis Chiral Technologies, 2001 Nolte Drive, West Deptford, New Jersey 08066, United States ‡ Johnson Matthey Catalysis Chiral Technologies, Orchard Road, Royston, Hertfordshire, SG8 5HE, United Kingdom ABSTRACT: Strategies for the development of Pd catalysts based on utilization of L2Pd and LPd species, beyond the contributions of the 2010 Nobel Laureates Richard Heck, Ei-ichi Negishi, and Akira Suzuki, along with their contemporaries, are reviewed. These well-deﬁned, preformed Pd catalysts improve the selectivity and activity of selected cross-coupling reactions by reducing the metal loading and the ligand-to-metal ratios. This review describes predominantly the development of Pd precatalysts over the last 10 years and highlights the beneﬁts often observed when using well-deﬁned preformed catalysts relative to those generated in situ. KEYWORDS: cross-coupling, palladium, precatalysts 1. INTRODUCTION pharmaceutical industries. The new trend of using appropriate, The 2010 Nobel Prize in Chemistry for Pd-catalyzed cross- well-deﬁned precatalysts vs catalysts generated in situ is coupling was one of the most highly anticipated awards within reviewed here by using representative results from our lab, the synthetic organic and organometallic chemistry commun- a