生物化学教学课件：信号转导通路.pptVIP

* Protein Kinases 1: GPCRs (5%), 2: Kinases (2.8% genome) ~ 25% of the mammalian intracellular proteins undergoes reversible phosphorylation * Protein kinases (534 human kinases) Ser/thr Kinases comprise 80% of all protein kinases AGC * Phosphorylation de-phosphorylation are the most common regulatory mechanisms, mediated by protein kinase and phosphatase, respectively 蛋白激酶 n NTP n NDP 蛋白质 蛋白质-n Pi n Pi 蛋白磷酸酶 H2O * 蛋白激酶（protein kinase，PK） ? 植物和酵母中～2%的基因编码蛋白激酶；而在哺乳动物中，高达5－8％。 ? 根据磷酸化靶蛋白的氨基酸残基的种类不同，蛋白激酶有丝氨酸/苏氨酸激酶、酪