现代生物质谱技术.pdfVIP

现代生物质谱技术 一、质谱的发展历史 Nobel Prize Winners for Mass Spectrometry Joseph John Thomson Francis William Aston 约瑟夫·约翰·汤姆逊 弗朗西斯·阿斯顿 Wolfgang Paul 1989 Nobel Prize in Physics 1906 Nobel Prize in Physics 1922 Nobel Prize in Chemistry John B. Fenn Koichi Tanaka 2002 Nobel Prize in Chemistry 2002 Nobel Prize in Chemistry Nobel Laureate (1906): Joseph John Thomson （约瑟夫·约翰·汤姆逊） (1856 - 1940) Cambridge University, Cambridge, Great Britain The Nobel Prize in Physics 1906. in recognition of the great merits of his theoretical and experimental investigations on the conduction of electricity by gases The first mass spectrometer  发现电子。 在这之前，一般都认为原子是 “不 能再分割的”。汤姆逊证实原子是由许多部分 组成的，并被称为 “一位最先打开通向基本粒 子物理学大门的伟人”。  创造了把质量不同的原子分离开来的方法，为 后人发现同位素奠定了基础。  在他的学生或同事中，有九位获得了诺贝尔奖。 Early Mass Spectrometry—The Physics Roots  The history of MS begins with J. J. Thomson of University of Cambridge.  Thomson’s “theoretical and experimental investigations on the conduction of electricity by gases” led to the discovery of the electron in 1897 （测定了电 子的荷质比）for which he was awarded the 1906 Nobel Prize in Physics.  Thomson constructed the first mass spectrometer (then called a parabola spectrograph, 抛物线光谱仪), in which ions were separated by