2021磷酸果糖激酶.ppt

糖酵解的调节 ? 糖酵解代谢途径的调节主要是通过各 种变构剂对三个关键酶进行变构调节。 1. 己糖激酶或葡萄糖激酶： 葡萄糖激酶是肝脏调节葡萄糖吸收的 主要的关键酶。 第 19 章 糖酵解 The committing step Regulatory ADP One subunit of the tetrameric phosphofructokinase-1 (PFK-1) The level of F-2,6-BP is controlled by the relative activity of PFK-2 and FBPase-2, which are located in one polypeptide chain and whose activities are regulated by glucagon-stimulated phosphorylation. C-1 no longer carries a large positive charge: hydride ion leaves readily Phosphorolysis （ 磷酸解作用 ） Proposed action mechanism Of glyceraldehyde 3-P dehydrogenase Energy-rich intermediate (thioester) Inactive enzyme Iodoacetate 碘醋酸 Pyruvate is decarboyxlated With the help of TPP, a coenzyme of pyruvate decarboxylase during ethanol fermentation