生化与分子实验技术及疾病机理图10567.pptVIP

* G1 S G2 M Activating mutation in cancer Inactivating mutation (deletion)in cancer Cell CycleControl Apoptosis Apaf1 CARD Apaf1 CARD Apaf1 CARD Casp 9 Casp 9 Casp 9 C C C Common Alterations in Melanoma Ras PTEN Ras Increased expression (no known direct mutation) p21 Decreased expression(No known direct mutation) Proliferation p53 PTEN PI3K Survival Apoptosis DNA Repair ELK1 AP1 PI 4,5 P2 PI 3,4,5 P3 CyclinD1 N-Ras ERK1/2 Grb2 Sos MEK1/2 EGFR MLH1 MSH2 CDKN2A c-Myc Wnt β- Catenin APC BRAF *