生化与分子实验技术及疾病机理图10562.pptVIP

* G1 S G2 M Activating mutation in cancer Inactivating mutation in cancer Cell CycleControl Apoptosis Apaf1 CARD Apaf1 CARD Apaf1 CARD Casp 9 Casp 9 Casp 9 C C C Common Alterations in Endometrial Carcinoma Ras PTEN Ras Increased expression (no known directmutation) p21 Decreased expression(No known directmutation) Proliferation HER2 Ras ERK1/2 Grb2 Sos Raf MEK1/2 p53 PTEN PI3K Survival Apoptosis DNA Repair p21 p16 MLH1 MSH2 MSH6 ELK1 AP1 cMyc PI 4,5 P2 PI 3,4,5 P3 *