完整文稿细生6 15 mct讨论课apoptosis.pptVIP

Conclusion Reference: 1.Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells 2.ROITT’S Essential Immunology 12th Edition Apoptosis in the regulation of Immune cells Part 1 1 2 3 4 目录 CONTENT Apoptosis Bcl-2 Mcl-1 Bim Apoptosis Mcl-1 Bcl-2 Bim Apoptosis in the regulation of Immune cells programmed cell death?(PCD) Different from necrosis(坏死） Universal Mcl-1 Bim Bcl-2 Apoptosis Dispensable Divide into 2 types:Inhibition of apoptosis →caspase →Promote apoptosis change mitochondrial membrane permeability→Pro apoptotic factor release regulate cell death (apoptosis) Oncogene(Damage to the Bcl-2 gene has been identified as a cause of a number of cancers) Universal Bim Apoptosis Mcl-1 Bcl-2 mechanism still not clear Its BH1 combines with the BH3 of Puma(a kind of protein which also belongs to Bcl-2 and promote apoptosis) and stop the cytochrome C relaese from mitochondrion can stop apoptosis when the amount of Puma is low(becaise of its instability) Apoptosis Bcl-2 Mcl-1 Bim Activated Bax or inhibited Bcl-2 or both make BH3-only protein binding to the Bcl2 protein tightly binds to the BH3-only protein with Bid like BH3 domain, causing mitochondrial pathway apoptosis. Part 2 Activation-induced Cell Death (AICD) Cell membrane: FasL+Fas Mitochondria: Imbalance of Bcl 2 Caspase 3 Caspase 8 Cleavage of ICAD-L CAD Cleavage of DNA FLIP thanks for listening！