50例进展期胃癌围手术期腹腔热灌注化疗的临床探讨.docVIP

50例进展期胃癌围手术期腹腔热灌注化疗的临床探讨 [摘要] 目的 分析胃癌患者围手术期采取腹腔热灌注化疗对于患者的意义，为后续的临床治疗提供方法参考。 方法 方便选取2012—2014年该院收治的100例进展期胃癌的患者，随机分为观察组及对照组。对照组术后静脉注射化疗，观察组采取腹腔热灌注化疗，比较两组的临床治疗效果。结果 术后观察组的CEA等肿瘤标志物水平明显低于对照组；观察组的局部复发率为12.0%，远处转移率为22.0%，对照组分别为40.0%及52.0%，两组差异有统计学意义（χ2=15.05、16.10）；两组不良反应发生率均为14.0%，差异无统计学意义（χ2=0.05），观察组1年及3年的生存率96.0%、60.0%，对照组为86.0%，36.0%，差异有统计学意义（χ2=4.06、6.59）。 结论 对于进展期胃癌的患者，在围手术期进行腹腔热灌注化疗，可以明显降低肿瘤标志物的含量，安全可行，提高患者的生存率。 [关键词] 胃癌；围手术期；腹腔热灌注化疗；临床疗效 [中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）08（b）-0044-03 Clinical Study of Abdominal Hyperthermic Perfusion Chemotherapy in 50 Patients with Advanced Gastric Cancer during Perioperative Period CAI Xiao-hong Department of Internal Medicine， People”s Hospital of Shenyang Economic and Technological Development Zone， Shenyang， Liaoning Province， 110041 China [Abstract] Objective To analyze the significance of abdominal hyperthermic perfusion chemotherapy in patients with gastric cancer during perioperative period， and provide a reference for follow-up clinical treatment. Methods 100 patients with advanced gastric cancer admitted to the department from 2012 to 2014 were conveniently selected and randomly divided into observation group and control group. The control group received intravenous chemotherapy after the operation and the observation group received intraperitoneal hyperthermic perfusion chemotherapy. The clinical treatment effects of the two groups were compared. Results The levels of CEA and other tumor markers in the postoperative observation group were significantly lower than those in the control group； the local recurrence rate in the observation group was 12.0%， the distant metastasis rate was 22.0%， and the control group was 40.0% and 52.0%， respectively， with significant difference （χ2=15.05， 16.10）； the incidence of adverse reactions in both groups was 14.0%， with no significant difference（χ2=0.05）. The 1-year and 3-year survival rates of the observation group were 96.0% and 60.0%， and that of the control group was