高迁移率族蛋白1英文文献汇报讲座教学PPT课件.ppt

3 3 3 These blood changes may reflect cerebrospinal fluid–to–blood (CSF-to-blood) transport of HMGB1, which is initially (within the first 3 hours) passively released from damaged neurons and possibly also from BBB endothelium . In particular, at 3 hours after SE, nonacetylated and reduced HMGB1 in blood overshot the brain changes by about 2-fold, suggesting an additional cellular source of HMGB1 other than the brain parenchyma, such as the brain endothelium. In accordance, endothelial cells showed increased expression of HMGB1 during epileptogenesis . Further, it has previously been demonstr