生物化学教学课件：lecture7 Fatty acid catabolism（脂肪酸代谢）.pdf

Lecture 7 FATTY ACID CATABOLISM （脂肪酸代谢） 生物化学教程p401-427 生物化学下册p230-p298 outline • fatty acid catabolism Triglycerides(甘油三酯) Utilization of Fatty Acids as Fuel Ketone bodies （酮体） Special Cases （自学内容） • Lipid biosynthesis Formation of Malonyl Coenzyme A （丙酰CoA ） Biosynthesis Elongation，unsaturation，biosynthesis of lipids and cholesterol （自学内容） Part Ⅰfatty acid catabolism Fatty acids play several important roles: 1) Building blocks for phospholipids(磷脂) glycolipids(糖脂) 2) Target proteins to membranes 3) High energy source of fuel 4) Fatty acid derivatives are used as hormones and intracellular messengers Overview of fat digestion, absorption, storage, and mobilization in the 1. Fatty acids in the body arise either human. from biosynthesis from acetyl-CoA or from breakdown of fats and phospholipids. 2. Fatty acids: transported in the blood complexed to serum albumin. 3. Unsaturated fatty acids: cis double bonds. 4. Common saturated fatty acids include palmitic acid(棕榈酸) and stearic acid(硬脂酸). 5. Common unsaturated fatty acids include oleic acid(油酸), palmitoleic