生物化学教学课件：lecture5 Glycogen（糖原代谢）.pdf

Lecture 5 Glycogen Synthesis and Breakdown 生物化学教程p390-400 生物化学下册p176-p195 1、introduction 2、Glycogen catabolism 3、Glycogen synthesis 4、Control of glycogen metabolism KEGG: Kyoto Encyclopedia of Genes and Genomes 锚泊蛋白合成 O-聚糖合成 硫酸软骨素合成 糖苷-鞘脂 粘多糖降解 红细胞糖苷 多糖合成和代谢 肽聚糖合成 神经节苷脂合成 • Glucose is stored as starch and glycogen in cytosolic granules in muscle and liver cells of vertebrates Glycogen particles in a liver cell section Glycogen structure 磷酸肌酸 Phosphorylase 磷酸化酶 Phosphorolysis -磷酸解(作用) is a displacement reaction in which phosphate is the attacking species and becomes covalently attached at the point of bond breakage -introduction of a phosphoryl group e.g. Glycogen phosphorylase phosphatase 磷酸（酯）酶 –dephosphorolysis, the removal of a phosphoryl group from a phosphate ester with water as the attacking species. e.g. Fructose bisphosphatase-1 （果糖-二磷酸酶-1）converts fructose 1,6- bisphosphate to fructose 6-phosphate in gluconeogenesis Fructose bisphosphatase-1 Glycogen Degradation (1) Glycogen Phosphorylase (糖原磷酸化酶) Glycogen Degradation (2) 糖原磷酸化酶 重点 Glycogen Degradation (3) 重点 Glycogen Degradation (4) 重点 Glycogen Degradation (5): -1,6 glucosidase 重点 Phosphoglucomutase