病理生理学课件：Chapter11 Coagulation and anticoagulation disturbance.pptVIP

2.Factors influencing the formation and development of DIC or Predisposing Factors to DIC （DIC诱因） Inappropriately conditioned monocytes-macrophages (单核-巨噬细胞受损） Macrophage 吞噬、清除血液中的凝血酶，纤维蛋白等促凝物 清除纤溶酶，FDP，内毒素等 坏死组织，细菌等“封闭”其功能 全身性Shwartzman反应 (2) Impairment of liver functions Liver cells producing PC/AT-III/fibrinogen inactivating IXa/Xa/XIa necrosis TF (3) Hypercoagulable status （血液高凝状态） Pregnancy Acidosis Infections (4) Dysfunction of microcirculation Shock stage II淤血.ppt 2. Predisposing Factors to DIC (1) Impairment of the reticuloendothelial (2) Impairment of liver functions (3) Hyper