病理解剖2班淋巴造血.pptxVIP

The Disease of Hematopoietic and Lymphoid SystemsHematopoietic and Lymphoid SystemsMyeloid tissueBone marrowRBC, platelets, granulocytes, monocytesLymphoid tissuelymph nodes thymus spleenDisorders encompass a wide range of diseases, involving its any organs or tissues.RBC: usually anemiaWBC: overgrowth, usually malignant common and lethal Neoplastic proliferations of white cellsBe defined briefly as follows:Myeloid neoplasms 髓样组织肿瘤Lymphoid neoplasms 淋巴样组织肿瘤HistiocytosisMan-made classification The distinction in some cases may be blurred.Myeloid neoplasmsArise within hematopoietic stem cells Three general categories:Acute myelogenous leukemia (AML 急性髓性白血病) Chronic myeloproliferative disorders （慢性骨髓增生性疾病）Chronic myelogenous leukemia 慢性髓性白血病Polycythemia vera 真性红细胞增生症Myeloid metaplasia with myelofibrosis 伴骨髓纤维化的髓样增生Essential thrombocythemia 真性血小板增生症Myelodysplastic syndromes（骨髓增生异常综合症）8 types: FAB classification M1~8Myeloid neoplasms: CD13,CD14,CD15,CD64Lymphoid neoplasms A group of entities that vary widely in terms of their clinical presentation and behaviorClassification scheme that relies on a combination of clinical, morphologic, phenotypic and genotypic features the relationship between lymphoma and lymphocytic leukemiaCertain important relevant principles most: B Cell origin neoplasms are often composed of cells that arrest at specific stagesLymphoid neoplasmsⅠA. Precursor B-cell neoplasmsⅠB. Peripheral B-cell neoplasms ⅡA. Precursor T-cell neoplasmsⅡB. Peripheral T-/NK-cell neoplasmsⅢ. Hodgkin lymphomaNHLⅠA. Precursor B-cell neoplasms 1. Precursor B-cell leukemia/lymphomaⅡA. Precursor T-cell neoplasms 1. Precursor T-cell leukemia/lymphomapre-B-lymphoblastic tumor: first leukemia lymphoma pre-T-lymphoblastic tumor: mediastinal masses involved the thymus leukemia Both tumors usually have the clinical appearance of an acute lymphoblastic leukemia (ALL) Clinical features1. Abrupt stormy onset—within 3 months2. Symptoms related to depression of n