生物化学与分子生物学课件signal transduction ii8版.pptxVIP

Section Ⅲsignaling pathways;receptors;Characters of receptors;Ⅰ.intracellular receptors; no hormone, inhibitory protein complex binds to DNA binding domain of receptor, prevents receptor entering cell nucleus. there is hormone, hormone binding changes the conformation of receptor, inhibitory protein complex dissociates and DNA binding domain and nuclear localization signal are exposed, hormone-receptor complex enters nucleus and binds to HRE in the DNA, acting as transcription regulators, modulates gene expression.;Ⅱ. Ion-channel receptors;Ⅲ. G Protein coupled receptors;N terminal: outside