皇冠背后的故事1115journal club.pptxVIP

Dang Lab’s Journal ClubER-stress-induced transcriptional regulation increases proteinsynthesis leading to cell deathJaeseok Han, Sung Hoon Back,Junguk Hur, Yu-Hsuan Lin, Robert Gildersleeve,Jixiu Shan, Celvie L. Yuan, Dawid Krokowski, Shiyu Wang, Maria Hatzoglou, Michael S. Kilberg, Maureen A. Sartor, and Randal J. KaufmanNat Cell Biol. 2013 May ; 15(5): 481–490.Zengxia Li11/15/2013UPR pathways Endoplasmic-reticulum-associated protein degradation (ERAD) ER stress induced cell death ﹖The paradox:CHOP: CHOP is required for ER stress-induced cell death ( Chop-/-); however, forced expression of C