乳腺癌辅助内分泌治疗相关试验.pptVIP

Cross-Over Design916 MBC 458 Letrozole 458 Tamoxifen Progression Cross-Over Progression Survival Follow-up Letrozole Tamoxifen 第二十一页，共34页 Letrozole Tamoxifen Response Rate (%) P0.001 P0.001 第二十二页，共34页 TTP: Kaplan-Meier Curve Letrozole Tamoxifen 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 0 3 6 9 12 15 18 21 24 Months Proportion of patients without progression 第二十三页，共34页 Femara? ( letrozole ) vs Tamoxifen as Pre-Operative Therapy 0 2 4 第二十四页，共34页 Design Double-blind, double-dummy, randomized, parallel group,multicenter (55 centers in 16 countries), ph