讲义参考说明教案391pituitary adrenal gland disease.pptxVIP

Pituitary and Adrenal gland disease;Anterior pituitary gland;Pituitary hormones;Pituitary Hormones;Dysfunction of pituitary;Hyperfunction of pituitary;gigantism;Hypopituitarism;Hypofunction of pituitary;gigantism;Pituitary Tumors;Definition of pituitary tumors;Production of hormones;classification;Clinical manifestations;Clinical manifestations;Treatment;Radiation used as an adjunct to surgery 50% develop hormonal deficiencies within 10 years Medical therapy Prolactin secreting tumors GH secreting tumors TSH secreting tumors;Pituitary Tumors;Prolactin:synthesis and secretion by pituitary lactotroph cells tonically suppressed by hypothalamic dopamine Factors inducing prolactin synthesis and secretion include estrogen, thyrotropin- releasing hormone, epidermal growth factor, and dopamine receptor antagonists. ;Etiology ;;Clinical features;Diagnosis of Hyperprolactinemia; When there is a discrepancy between a very large pituitary tumor and a mildly elevated prolactin level, recommend serial dilution of serum samples to eliminate an artifact that can occur with some immunoradiometric assays leading to a falsely low prolactin value (“hook effect”);Diagnosis of hyperprolactinemia;Management;;Etiology(Adult type); posthypophysectomy fracture of skull Irradiation metastatic tumor autoimmune hypophysitis infectious disease; Hypopituitarism ; Clinical manifestations due to deficiency of pituitary hormones ; Clues for Diagnosis of Hypopituitarism;Clinical manifestations due to intracranial space occupying lesion(if present);Hypopituitarism ;Management of hypopituitarism;Adrenal diseases;The history of Cushing’s syndrome ;Cushing’s syndrome ( Hypercortisolism) Cushing’s syndrome cortisol↑ from Cushing’s disease ACTH ↑ from;Cushing’s syndrome; ACTH dependent