宫颈癌组织CD44v6表达的意义.doc

1??±°?×é?ˉCD44v6±í′?μ?òaò? ×÷??￡o??oì??o???????D¤??????????????à??÷?ú ??1??ü′ê??1??±?×á? 1??ü′ê:CD44;1??±?×á?;?aò?×é?ˉ?ˉ?§ ?aòa:??μ?ì?ì?CD44v6?ú1??±°??°2?±??°1??±°??Dμ?±í′??°??áù′2òaò?.·?·¨ó|ó?S-P?aò?×é?ˉ·¨1?2ì1??±°?60ày?￠?y3￡1??±é??¤×é?ˉ10àyoí1??±é??¤?úá??ù2?±?￡¨CIN￡?12ày?DCD44v6μ?±í′?.?á1??y3￡1??±é??¤×é?ˉ?DCD44V6??D??ê?a20%￡?CIN?DCD44v6??D??ê?a42%￡???1??±°?×é?ˉ?DCD44v6??D??ê?a68%.?ú1??±°??D￡???2?àí·???μ?éy??￡?CD44v6±í′????ó￡???￠?￡?￠ò?°￠ó??CD44v6??D??ê·?±e?a43%￡?69%oí85%￡¨Plt;0.05￡?.CD44v6±í′??úóDáü°í?á×aò?×é?D￡¨91%￡??÷????óú?Táü°í?á×aò?×é￡¨52%￡?Plt;0.05￡?.áù′2·??úííCD44v6±í′???￡?￠?￡?￠ò?úoí￠ó￡?￠??úCD44v6??D??ê·?±e?a63%oí80%￡?μ??Tí3???§òaò?￡¨Pgt;0.05￡?.?á????×?1??±°?μ?·￠éú?￠·￠?1￡?CD44v6±í′??ê?e?￥???ó￡?CD44v6?é×÷?a?D??1??±°???D?3ì?è?￠×aò??°?¤oóμ???òa??±ê. ????Keywords:CD44;cervixneoplasms;immunohistochemistry ????Abstract:AIMToStudytheclinicalsignificanceofCD44v6expressionincervicalcancer.METHODSSpecimensof60cervicalcancer￡?10normalcervicalepitheliaand12cervicalintraepithelialneoplasia￡¨CIN￡?wereexaminedforCD44v6expressionbyimmunohistochemicalstaining.RESULTSPositivestainingwasseenin20%ofnormalcervicalepithe-lia￡?42%ofCIN￡?68%ofcervicalcancer.Incervicalcancer￡?thefrequencyofabnormalCD44v6expressionwascorrelated topathologicgradeandlymphnodemetastasis￡¨Plt;0.05￡?.Thehigherthepathologicgradeoftumor￡?themoretheex-pressionofCD44v6.PositiveCD44v6expressionwassignifi-cantlymorefrequentintheadvancedstageofcervicalcancerwithlymphnodemetastasis.CONCLUSIONDecreasedex-pressionofCD44v6isausefulparameterofcervicalmalig-nancy. ????0òy?? ????CD44ê?×??÷òaμ???°??3??·?×ó??ò?￡?òò???éμ?×??×á???°?ó??T?÷??°?oí??°?ía?ù?êμ??à?￥×÷ó?￡???3é?a?D???×á?×aò??°?¤oóμ?èèμ?￡?1￡?2￡Y.???Dò?o?óDía??×óv6μ?CD44±?òìì?￡¨CD44v6￡?ó??à???×á?μ?éú3¤?￠?????￠×aò?oí?¤oóóD1?￡?1￡Y.?ò??ó|ó??1CD44v6?1ì?í¨1y?aò?×é?ˉ·¨?D???ú1??±°??°??°??°2?±??Dμ?±í′??°??áù′2òaò?. ????12?á?oí·?·¨ ????1.12?á??ò?o1998/1999?-ê?ê??D3yμ?￠?￡?￠ò?ú1??±°?±ê±?40ày￡?2??üê?ê?μ?￠ó￡?￠??ú1??±°????ì±ê±?20ày.?êá?29??70￡¨???ù49￡??ê.2?