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Biochem. J. (2009) 420, 391–402 (Printed in Great Britain) doi:10.1042/B 391 Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/γ -secretase activity 1 1 1 Svenja RIEDLE* , Helena KIEFEL* , Daniela GAST* , Sandra BONDONG*, Silke WOLTERINK*, Paul GUTWEIN† and Peter ALTEVOGT*2 *Translational Immunology, D015, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Federal Republic of

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