COX2抑制剂在术后镇痛的临床应用医学.pptVIP

1 * 1 * 1 * The incidence of endoscopically detected upper GI ulceration was significantly lower with DYNASTAT? (parecoxib sodium for injection) than with the nonselective NSAIDs, ketorolac and naproxen.1-3 Both oral and injectable NSAIDs studied produced significantly more ulceration than DYNASTAT (P ≤0.05)1-3 The incidence of gastroduodenal ulceration with DYNASTAT was comparable to placebo1-3 This graph reflects the combined incidence of gastroduodenal ulcers from 3 different 7-day endoscopic trials in healthy subjects1-3 The GI ulceration/bleeding associated with nonselective NSAIDs is