浙江大学《遗传学》课件-chapter6 mt.pptVIP

2. mtDNA genes have a much higher mutation rate than nuclear DNA genes. Mutation rate is 10 fold than nuclear DNA genes 3. Many of the pathogenic mtDNA mutations are heteroplasmic. For expression of a disease it is required that a certain threshold level of mutant mtDNA should be exceeded. 3. Homoplasmy Heteroplasmy Homoplasmy: The presence of only one type of mtDNA in the mitochondria of a single individual. Heteroplasmy: The presence of more than one type of mtDNA in the mitochondria of a single individual. Inheritance and expression variable bec