MRS联合VBM对首发抑郁症患者海马代谢和结构的研究.docxVIP

MRS联合VBM对首发抑郁症患者海马代谢和结构的研究 　　【摘要】目的：运用多体素三维磁共振波谱（3d-1h-mrs）和基于体素的形态测量（voxelbasedmorphometry，vbm）方法分析首发抑郁症患者双侧海马代谢物改变和结构体积变化特点，评价海马1h-mrs及体积变化在首发抑郁患者早期诊断的应用价值。方法：测量40例首发抑郁患者和20例健康者双侧海马体积及肌酸（cr）、n-乙酰天门冬氨酸（naa）、胆碱（cho）峰下面积，计算出naa/cr、cho/cr比值，并进行统计学分析。结果：首发抑郁组右侧海马naa/cr、cho/cr及cho值低于对照组，差异均有统计学意义（p0.05）;两组其余代谢指标比较差异无统计学意义（p0.05）;首发抑郁组双侧海马体积与健康组比较差异无统计学意义（p0.05）。结论：多体素3d-1h-mrs可为临床医生早期诊断首发抑郁提供参考。 　　【关键词】首发抑郁症磁共振波谱形态测量法海马 　　doi：10.14033/j.cnki.cfmr.2019.28.026文献标识码b文章编号1674-6805（2019）28-00-03 　　metabolismandstructureofhippocampusinfirst-episodedepressivepatientsbymrscombinedwithvbm/lizonghong，huxiao，wangxiao，wangchun，hujun，lichenglin，xiaochaoyong，liuxianwei.//chineseandforeignmedicalresearch，2019，17（28）：-65 　　[abstract]objective：toanalyzethemetaboliccharacteristicsandthestructurechangesofhippocampusby3dmultivoxelprotonmagneticresonancespectroscopy（3d-1h-mrs）andvoxelbasedmorphometry（vbm）infirst-episodedepression.toevaluatethevalueof1h-mrsandvolumechangesinhippocampusinearlydiagnosisoffirst-episodedepression.method：atotalof40depressivepatientsand20normalcontrolswereassessedinthisstudy.naa、crandchopeakareaweredetectedindifferentareas，thevolumeofhippocampus，andnaa/cr，cho/crratiowerecalculatedandanalyzedstatistically.result：thefirst-episodedepressivegrouphadsignificantlylowerchovalue，naa/crandcho/crratioinrighthippocampusthanhealthgroup，thedifferenceswerestatisticallysignificant（p0.05）.nosignificantdifferenceswerefoundinothermetabolicvaluesbetweenthetwogroups（p0.05）.therewerenosignificantdifferencesinthevolumeofhippocampusbetweenthefirst-episodedepressivegroupandthehealthgroup（p0.05）.conclusion：multivoxel3d-1h-mrscanprovidereferenceforclinicianstoearlydiagnosisofdepression. 　　[keywords]first-episodedepressivemagneticresonancespectroscopyvoxelbasedmorphometryhippocampus 　　first-author’saddress：nanjingbrainhospitalofnanjingmedicaluniversity，nanjing210029，china 　　抑郁症（majordepression，md）以情感低落、思维迟缓及言语动作减少、迟缓为典型症状，其发病机制仍未完全阐明[1-3]。海马对学习、记忆和情绪等脑高级功能活动有