唑来膦酸联合放疗治疗恶性肿瘤骨转移患者的效果.docxVIP

唑来膦酸联合放疗治疗恶性肿瘤骨转移患者的效果 　　摘要：目的觀察唑来膦酸联合放疗治疗恶性肿瘤骨转移患者的临床疗效。方法选取2018年5月～2019年5月在我院诊治的76例恶性肿瘤骨转移患者临床为研究对象，采用随机数字表法分为对照组和观察组，各38例。对照组采用单纯放疗治疗，观察组在对照组基础上联合唑来膦酸治疗，比较两组临床治疗骨转移灶疗效评总有效率、疼痛评分、生活质量以及临床不良反应发生情况。结果观察组骨转移灶治疗总有效率为57.89%，高于对照组的44.73%（p0.05）;治疗后两组疼痛评分均低于治疗前，且观察组低于对照组（p0.05）;治疗后两组生活质量评分高于治疗前，且观察组高于对照组（p0.05）;观察组不良反应发生率为15.78%，与对照组的18.42%比较，差异无统计学意义（p0.05）。结论唑来膦酸联合放疗治疗恶性肿瘤骨转移效果确切，可减轻患者疼痛，提高生活质量，且不增加临床不良反应。 　　关键词：唑来膦酸;放疗;恶性肿瘤;骨转移 　　中图分类号：r730.53文献标识码：adoi：10.3969/j.issn.1006-1959.2020.09.044 　　文章编号：1006-1959（2020）09-0138-02 　　theeffectofzoledronicacidcombinedwithradiotherapyinpatients 　　withbonemetastasesfrommalignanttumors 　　libo 　　（departmentofoncology，jiamusicentralhospital，jiamusi154002，heilongjiang，china） 　　abstract：objectivetoobservetheclinicalefficacyofzoledronicacidcombinedwithradiotherapyinthetreatmentofpatientswithmalignantbonemetastases.methods76patientswithbonemetastasesfrommalignanttumorsdiagnosedandtreatedinourhospitalfrommay2018tomay2019wereselectedastheresearchsubjects，theyweredividedintoacontrolgroupandanobservationgroupwithrandomnumbertablemethod，with38casesineachgroup.thecontrolgroupwastreatedwithradiotherapyalone，andtheobservationgroupwastreatedwithzoledronicacidonthebasisofthecontrolgroup.thetotaleffectiverate，painscore，qualityoflifeandclinicaladversereactionsoftheclinicaltreatmentofbonemetastasesinthetwogroupswerecompared.resultsthetotaleffectiverateofbonemetastasesintheobservationgroupwas57.89%，whichwashigherthan44.73%inthecontrolgroup（p0.05）;thepainscoresofbothgroupsaftertreatmentwerelowerthanbeforetreatment，andtheobservationgroupwaslowerthanthecontrolgroup（p0.05）;aftertreatment，thequalityoflifescoreofthetwogroupswashigherthanbeforetreatment，andtheobservationgroupwashigherthanthecontrolgroup（p0.05）;theincidenceofadversereactionsintheobservationgroupwas15.78%，comparedwith18.42%ofthecontrolgroup，thedifferencewasnotstatisticallysignificant（p0.05）.conclusionzoledronicacidcombinedwithradiotherapyhasadefiniteeffecton