AS1949490-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE AS1949490 Cat. No.: HY-18686 CAS No.: 1203680-76-5 分⼦式: C₂₀H₁₈ClNO₂S 分⼦量: 371.88 作⽤靶点: Phosphatase 作⽤通路: Metabolic Enzyme/Protease 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 AS1949490 是⼀种有效的、选择性的 SHIP-2 的抑制剂，其IC50 值为 620 nM。AS1949490 通过上调L6肌管 GLUT1基因激活葡萄糖代谢。 IC50 Target IC50: 620 nM (SHIP-2) [1]. REFERENCES [1]. Suwa A, et al. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol. 2009 Oct;158(3):879-87. [2]. Suwa A, et al. Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur J Pharmacol. 2010 Sep 10;642(1-3):177-82. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021 Fax: 021