Asimilobine-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Asimilobine Cat. No.: HY-N7512 CAS No.: 6871-21-2 分⼦式: C₁₇H₁₇NO₂ 分⼦量: 267.32 作⽤靶点: Dopamine Receptor; 5-HT Receptor; Parasite 作⽤通路: GPCR/G Protein; Neuronal Signaling; Anti-infection 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Asimilobine 是从⽊兰的植物中分离出的⼀种阿朴啡型异喹啉⽣物碱。Asimilobine 是多巴胺 (dopamine) ⽣物 合成的抑制剂，也是⾎清素能受体 (serotonergic receptor) 拮抗剂。Asimilobine 具有抗疟 (antimalarial) 和抗 癌活性。 IC50 & Target Dopamine Receptor serotonergic receptor 体外研究 Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM [2]. Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h [2]. Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels [2]. REFERENCES