Autocamtide-2-related-inhibitory-peptide-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Autocamtide-2-related inhibitory peptide Cat. No.: HY-P0214 CAS No.: 167114-91-2 分⼦式: C₆₄H₁₁₆N₂₂O₁₉ 分⼦量: 1497.74 Sequence: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu Sequence Shortening: KKALRRQEAVDAL 作⽤靶点: CaMK; Autophagy 作⽤通路: Neuronal Signaling; Autophagy 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Autocamtide-2-related inhibitory peptide 是⾼度特异性的、CaMKII 的有效抑制剂，其IC50 值为 40 nM。 IC50 & Target IC50: 40 nM (CaMKII) [1]. 体外研究 It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used [1]. REFERENCES [1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12. McePd