Apelin-36-human-TFA-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Apelin-36(human) TFA Cat. No.: HY-P1064A 分⼦式: C₁₈₆H₂₉₈F₃N₆₉O₄₅S 分⼦量: 4309.85 Sequence: Leu-Val-Gln-Pro-Arg-Gly-Ser-Arg-Asn-Gly-Pro-Gly-Pro-Trp-Gl n-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser- His-Lys-Gly-Pro-Met-Pro-Phe Sequence Shortening: LVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF 作⽤靶点: HIV 作⽤通路: Anti-infection 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Apelin-36(human) TFA 是⼀种内源性孤⼉ G 蛋⽩偶联受体 APJ 激动剂，EC50 为 20 nM。Apelin-36(human) TFA 对 HEK 293 细胞表达的⼈ APJ 受体有很⾼的亲和⼒ (pIC50=8.61)。Apelin-36(human) TFA与两种主要的 ⽣物活性有关：⼼⾎管和代谢。Apelin-36(human) TFA 抑制 HIV-1 和 HIV-2进⼊表达 APJ 的NP2/CD4细胞。 IC50 & Target HIV-1 HIV-2 REFERENCES [1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476. [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterizati