Deac-SS-Biotin-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Deac-SS-Biotin Cat. No.: HY-144793 分⼦式: C₃₅H₄₅N₃O₁₀S₃ 分⼦量: 763.94 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Deac-SS-Biotin 是⼀种有效的抗癌剂。Deac-SS-Biotin 通过⽣物素介导的内吞作⽤摄取进⼊细胞。Deac-SS- Biotin 与 DTT (⾕胱⽢肽) 结合可有效抑制微管组装并显⽰出更强的抗肿瘤活性 [1]。 体外研究 Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release [1]. Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin [1]. Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity [1]. Cell Proliferation Assay [1] Cell Line: SGC-7901, A549, Hela, L929 cells Concentration: 0-20 µM Incubation Time: 72 h Result: Showed potent antiproliferative activity with IC50s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells. Cell Viability Assay [1] Cell Line: A549 cells