NaPi2b-IN-3-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE NaPi2b-IN-3 Cat. No.: HY-146429 CAS No.: 2227443-66-3 分⼦式: C₄₅H₅₁N₅O₇ 分⼦量: 773.92 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 NaPi2b-IN-3 (compound 5) 是⼀种有效的钠依赖转运蛋⽩ 2b (SLC34A2, NaPi2b) 抑制剂，对⼈和⼤⿏的 NaPi2b IC50 分别为 71 nM 和 28 nM。NaPi2b-IN-3 可⽤于⾼磷⾎症的研究 [1]。 体内研究 NaPi2b-IN-3 (1 mg/kg for IV and 10mg/kg for PO; single dosage) exhibits good activity and moderate hydrophobicity, and systemically exposes to some extent [1]. Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats [1]. IV (1 mg/kg) PO (10 mg/kg) AUC0-t (h·ng/mL)834 ± 3531090 ± 430 Cmax (ng/mL)568 ± 261F (%)13.1 Animal Model: Sprague-Dawley rats [1] Dosage: 1 and 10 mg/kg Administration: IV and PO; single dosage Result: Exhibited good activity and moderate hydrophobicity and systemically exposed to some