PAK1-IN-1-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE PAK1-IN-1 Cat. No.: HY-146681 CAS No.: 2485732-30-5 分⼦式: C₂₆H₂₀ClN₅O₂ 分⼦量: 469.92 作⽤靶点: PAK 作⽤通路: Cell Cycle/DNA Damage; Cytoskeleton 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 PAK1-IN-1 是⼀种有效的选择性 PAK1 抑制剂，IC50 为 9.8 nM。PAK1-IN-1以剂量依赖性⽅式抑制 PAK1 相关 肿瘤细胞的迁移和侵袭 [1]。 IC50 & Target PAK1 PAK4 9.8 nM (IC50) >10 μM (IC50) 体外研究 PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively [1]. Cell Proliferation Assay [1] Cell Line: MDA-MB-231, HCT-116 cells Concentration: 1 µM Incubation Time: 72 h Result: Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively. Western Blot Analysis [1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10, 20 µM 1/2 Master of Bioactive