医学微生物学课件-第32章朊粒.pptxVIP

Chapter 32 朊粒(Prion)仅有蛋白质, 无核酸多beta折叠, 对蛋白酶的抗性引起人库鲁病, 克-雅病Cellular prion protein (PrPc) can be identical to scrapie like prion protein(PrPsc) in its protein sequence but differs in tertiary structure. PrPcPrionPsc1/28/2023医学微生物学第1页，共7页。 Simplified model for prion disease. PrPsc, acts as a template. It associates with the helical form allowing the latter to be converted to the beta-pleated sheet resistant form There are now two molecules of the resistant form that can act as a template and so the process accelerates 1/28/2023医学微生物学第2页，共7页。 PrionPsc的抵抗力PrP抵抗力强，对甲醛，戊二醛，乙醇，蛋白酶, 标准高压灭菌法等具