细胞凋亡和细胞自噬专题培训课件.pptx

Outline;第一节 凋亡旳研究历史;1980 Wyllie Biochemical changes in apoptotic morphology: - DNA fragmentation -Requires expression of death genes 1988 Bcl-2 was found to be anti-apoptotic 1991 ced genes were identified in C. elegan 1992 Fas/APO-1/CD95 was identified 1993 A role of p53 in regulation of apoptosis was described Fas ligand was identified ICE was found to be homolog of ced-3 in mammalian IAPs were identified 1994 The role of mitochondria during apoptosis 1996 The role of caspases during a