Cenderitide-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Cenderitide Cat. No.: HY-P3624 CAS No.: 507289-11-4 分⼦式: C₁₅₈H₂₆₃N₄₉O₅₀S₃ 分⼦量: 3745.27 Sequence Shortening: GLSKGCFGLKLDRIGSMSGLGCPSLRDPRPNAPSTSA (Disulfide bridge:Cys6-Cys22) 作⽤靶点: Guanylate Cyclase 作⽤通路: GPCR/G Protein 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Cenderitide 是⼀种有效的颗粒鸟酰基环化酶受体 (pGC) 激动剂。Cenderitide 是⼀种由 C 型利钠肽 (CNP) 与⽯ 斛利钠肽 (DNP) 的 C 端融合⽽成的利钠肽 (NP) 。Cenderitide 可激活 pGC-A 和 pGC-B，激活第⼆信使 cGMP，抑制醛固酮 (aldosterone)，在不降低⾎压的情况下保持 GFR 。Cenderitide 可⽤于⼼⼒衰竭的研究。 体外研究 Cenderitide has antiproliferative, anti-fibrotic, and anti-hypertrophic properties [1]. 体内研究 In vivo in normal canines, Cenderitide (10, 50, and 100 ng/kg) is a potent cGMP stimulator that has renal enhancing and cardiac unloading effects, with less reduction of blood pressure [1] [4]. REFERENCES [1]. Ichiki T, et al. Natriuretic peptide based therapeutics for heart failure: Cenderitide: A no