CDK2-4-6-IN-1-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE CDK2/4/6-IN-1 Cat. No.: HY-148213 CAS No.: 2803837-13-8 分⼦式: C₂₂H₂₂N₄O₄S 分⼦量: 438.5 作⽤靶点: CDK 作⽤通路: Cell Cycle/DNA Damage 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 CDK2/4/6-IN-1 (example 29) 是⼀种 CDK2/4/6 抑制剂，作⽤于 CDK2、CDK4、CDK6 的 IC50 值分别是 2.5、 23.7 和 44.3 nM。可⽤于癌症研究。 IC50 Target CDK2 CDK4 CDK6 2.5 nM (IC50) 23.7 nM (IC50) 44.3 nM (IC50) 体外研究 CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits the proliferation of OVCAR3 and MCF7 cells with the IC50 values of 14.6 and 117.8 nM, respectively [1]. CDK2/4/6-IN-1(example 29) (0-600 nM, 24 h) inhibits phosphorylation of Rb protein in OVCAR3 and MCF7 cells with the IC50 values of 18 and 581 nM, respectively [1]. 体内研究 CDK2/4/6-IN-1(example 29) (25 mg/kg or 50 mg/kg, once a day, orally) has a significant inhibitory effect on