(47)--免疫耐受的形成.pptVIP

Jujiyu,Immu Dept. Jujiyu,Immu Dept. * 02704 * Need for tissue and organ graft drove the curiosity to understand the mechanisms of tolerance. The observations a zoologist, Owens, that Dizygotic bovine twins could accept grafts from each other but their siblings from other pregnancies could not tolerate such grafts led Medawar to perform a series of experiments to induce tolerance in mice. 免疫耐受的形成 * 机体免疫系统对特定抗原的“特异性免疫不应答”的现象，称为免疫耐受。 特征： 1.免疫耐受具有免疫特异性 2.不影响免疫应答的整体功能 3.不同于免疫抑制或免疫缺陷 自身耐受可以避免自身免疫病的发生 免疫耐受（immunological tolerance) * Owen于1945年首先报道了在胚胎期接触同种异型Ag所致的免疫耐受现象 异卵双