生化郑利民生化引论－郑利民.pptxVIP

生化郑利民生化引论－郑利民;;Wonderful world：Garden of Eden;Amazing?!;第5页/共108页; Definition of Biochemistry;The Chemical Unity of Diverse Lives;Music in our body!;Main Questions for Biochemistry I (this semester):; All chemical process associated with organisms at the molecular level - isolate molecules and determine their structure - analyze their function Example: the study of DNA How life began and evolved Organisms: uniform at the molecular level indicate: they arose from a common ancestor ;1. Protein Structure and Function** （蛋白质的结构和功能） 2. Enzymes: Basic Concepts and Kinetics (酶的基本概念及酶促动力学) 3. Enzymes: Catalytic Regulatory Strategies （酶催化和调控的策略） 4. Carbohydrates（碳水化合物）** 5. RNA, DNA, and flow of genetic information ** (DNA,RNA及遗传信息的传递);6. Lipids and Cell Membranes（脂质和细胞膜） Bio-Signaling (生物信号通路） （Lehninger 和Biochemistry 第1 - 13章） 8. Responding to Environmental Changes The sensory systems The Immune system Biochemistry:Chpt. 32 33 ;Part II Transducing and Storing Energy （能量的转换和贮存） Part III Synthesizing the Molecules of Life （生物分子的合成）; The Aims of this Courses;Biochemistry ;;Biochemistry and Medicine Diagnosis Biochemical changes: enzymes, sugar etc Immunological Methods Gene diagnosis: chips (Gene Protein chips) Therapy Chemotherapy (most medicine cure the diseases by selective modulate host biochemical metabolite) Gene therapy of cancer, AIDS, genetic disease;Stage I 1870s’~1930s’ -- Chemical Constitution of Living Organisms;A Brief History of Biochemistry over the last 200 years (milestones);1920s James Sumner: Enzymes are proteins. 1940s - 1950s Avery and Hershey: DNA carries the genetic information. 1950s Franklin, and Watson and Crick: DNA is a double helix. 1960s Nirenberg: Genetic codes deciphered. 1980s Cech: RNA has catalytic activity (Ribosome).;Pauling the nature of chemical bond; the structure of proteins and other macromolecules;