针刺结合音乐疗法治疗中年女性轻度抑郁症的临床研究.docxVIP

针刺结合音乐疗法治疗中年女性轻度抑郁症的临床研究 【摘要】 目的：探究针刺结合音乐疗法治疗中年女性轻度抑郁症的效果及可能的机制。 方法：将60名中年女性轻度抑郁症患者随机分为治疗组和对照组。治疗组接受8次针刺结合音乐疗法治疗，每次治疗时间为40分钟。对照组接受8次纯音乐疗法治疗，每次治疗时间为40分钟。比较治疗前后两组受试者的汉密尔顿抑郁量表（HAMD）和抑郁自评量表（SDS）总分以及生活满意度、心理弹性和自我效能感等指标，并采取心理补偿与神经影像学分析探究可能的机制。 结果：治疗组治疗后HAMD和SDS总分明显低于治疗前，而对照组差异不显著。治疗组生活满意度、心理弹性和自我效能感等指标明显优于对照组。心理补偿实验证实治疗组相比对照组内侧前额叶、中央后回、背外侧前额叶、背内侧前额叶、背内侧中央后回以及腹内囊核、红核等区域更活跃。神经影像学分析显示治疗组相比对照组静息态下前扣带回、内嗅皮质、背外侧前额叶等区域灰质体积增加，且背内侧中央后回和前额叶下回白质连接增强。 结论：针刺结合音乐疗法可以显著改善中年女性轻度抑郁症的症状，并且可能通过调节内部神经网络和改善心理因素提高生活质量和心理弹性。 【关键词】针刺；音乐疗法；中年女性；轻度抑郁症；心理补偿；神经影像学 【Abstract】 Objective: To investigate the effect and possible mechanism of acupuncture combined with music therapy in the treatment of mild depression in middle-aged women. Methods: Sixty middle-aged women with mild depression were randomly divided into treatment group and control group. The treatment group received 8 sessions of acupuncture combined with music therapy, with each session lasting 40 minutes. The control group received 8 sessions of pure music therapy, with each session lasting 40 minutes. The Hamilton Depression Scale (HAMD), Self-rating Depression Scale (SDS), life satisfaction, psychological resilience, and self-efficacy were compared before and after treatment in the two groups, and psychological compensation and neuroimaging analysis were used to explore possible mechanisms. Results: After treatment, the total scores of HAMD and SDS in the treatment group were significantly lower than those before treatment, while the difference in the control group was not significant. The indicators of life satisfaction, psychological resilience, and self-efficacy in the treatment group were significantly better than those in the control group. Psychological compensation experiments confirmed that the areas such as the medial prefrontal cortex, central posterior gyrus, dorsolateral prefrontal cortex, dorsal medial prefrontal cortex, dorsomedial prefrontal cortex, and subthalamic nucleus and red nucleus were more active in the treatment