哪些因素导致乳腺癌患者死亡风险增加?癌症基因组(TCGA)数据分析库生存分析.docx

PAGE PAGE 1 What factors contribute to the increased risk of death in breast cancer patients? Survival analysis of the Cancer Genome Analysis (TCGA) database Content TOC \o 1-3 \h \u 11849 1 Introduction 2 20045 2 Data and Methods 3 7815 2.1 Data Source 3 12218 2.2 Descriptive Statistics 4 32366 2.3 Methods 5 13212 3 Analysis 5 30624 3.1 Estimation and Analysis of Cox Regression Model 5 27289 3.2 Diagnosis of Cox Regression Model 7 22418 4 Conclusion 8 30252 Reference 10 1 Introduction In order to explore the correlation between patient clinical test data and disease progression, the main methods of analysis used are linear regression, logistic regression and mixed-effects linear models. These methods allow for the selection of influences on clinical data related to disease progression and the determination of the magnitude of the influence on disease progression (Hubbard et al., 2010). However, these methods only consider the relationship between patient clinical examination information and disease progression and do not consider the impact of patient survival time on disease progression (Zhao et al., 2011). Survival time is the time taken for an event to change from one state to another. Where the event can be whether the patient dies, whether the disease progresses, etc., the time taken for such event state changes is collectively referred to as survival time. Survival analysis methods are beginning to be applied to clinical medicine data in order to allow for the integration of patient survival time and patient clinical data to evaluate disease progression (Casulo et al., 2015). ). In contrast to several other commonly used methods, survival analysis takes into account the impact of patient survival time on disease progression and helps physicians to understand how patients progress over time. Survival analysis is a method of statistical analysis that combines the outcome of an event with the survival time experienced for that outcome