文稿说明万钧sgc stimulators.pdfVIP

Update on sGC stimulators in PH: PAH and CTEPH trials and beyond Hossein-Ardeschir Ghofrani University of Giessen Lung Center Kerckhoff Heart and Lung Center Bad Nauheim 1 Signalling pathways in PH 2 Riociguat: sGC Stimulator • Oral stimulator of soluble guanylate cyclase (sGC) • Acts independently of nitric oxide (NO) • Targets reduced form of sGC • Enhances the sensitivity of sGC to low level