志贺菌主动外排泵acrAB-to1C及调控基因marOR突变与耐药的关系的开题报告.docxVIP

志贺菌主动外排泵acrAB-to1C及调控基因marOR突变与耐药的关系的开题报告 Title: The relationship between the mutation of the active efflux pump acrAB-to1C and the regulatory gene marOR in Shigella and drug resistance Introduction: Shigella, a genus of Gram-negative bacteria, is the causative agent of shigellosis, a highly infectious disease that causes diarrhea, fever, and abdominal cramps. The emergence of drug-resistant strains of Shigella has become a significant public health concern worldwide. One of the mechanisms that Shigella uses to resist antibiotics is through the active efflux pump, AcrAB-to1C, which pumps out d