ABHD2调控肺泡Ⅱ型上皮细胞凋亡 在慢性阻塞性肺疾病发生中的作用.pptVIP

Abhd2 regulates alveolar type Ⅱ apoptosis and airway smooth muscle remodeling: a key target of COPD research Shoude JinHarbin Medical University, China COPD ------ a silent killerThird cause of death in the worldFifth of the worlds disease burdenEarly diagnosis and early prevention are essentialInsidious, diagnosed at late stages…Background Airway remodeling Normal bronchial Abnormal bronchialPathophysiologyNormal vesselAbormal vesselVessel remodeling Smoking is a major risk factor for COPDOnly 10-20% of long-term heavy smokers develop into COPDPart COPD patients with no history of smokingtext2EnvironmentGeneticsClinical characteristics and prevention direction of COPD :： Interaction of individual genetic susceptibility and environmental factors It is important of susceptible early screening and early intervention in the prevention of chronic obstructive pulmonary diseaseThe importance of genetic susceptibility to COPD Recent Advances and trends:Genomic analyses to reveal genetic susceptibility to COPDRegional and Ethnic differences: α1-AT deficiency increase the risk of Caucasian COPD, it is a susceptibility gene for COPD TNFα gene mutation associated with Asian COPD such as EPHX1, IL4, IL-10 associated with COPD In addition to α1-AT, it has not been determined that other genes are susceptibility gene for COPD 1Our previous studyIL-13 G + 2044A point mutations associated with Caucasian COPD, but no correlation with the Chinese COPD patients (2021, Molecular Biology Reports, Dr. Shoude Jin and colleagues)Key Findings: Abhd2 gene deletion in mice naturally develop into emphysema phenotype (2021, BBRC， Dr. Shoude Jin and colleagues) Abhd2 protein is a lipid hydrolaseABHD2 homologous gene mutations can increase the risk of COPD〔2021, Plos one， Dr. Shoude Jin and colleagues 〕23 Yamamura team (our collaborators) Kumamoto University, JapanAbhd2 mouse gene expresses in alveolar type Ⅱ epithelial cells and airway smooth muscle cellsTrapping vector inser