A bi-ventricular cardiac atlas built from 1000+ high resolution MR im学习资料文件ages of healthy subjects and an analysis of shape and motion.pdfVIP

Medical Image Analysis 26 (2015) 133–145 Contents lists available at ScienceDirect Medical Image Analysis journal homepage: /locate/media A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion a,∗ a b b b Wenjia Bai , Wenzhe Shi , Antonio de Marvao , Timothy J.W. Dawes , Declan P. O’Regan , Stuart A. Cook b,c, Daniel Rueckert a a Biomedical Image Analysis Group, Department of Computing, Imperial College London, UK b MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, UK c National Heart Centre Singapore, Singapore, Duke-NUS Graduate Medical School, Singapore a r t i c l e i n f o a b s t r a c t Article history: Atlases encode valuable anatomical and functional information from a population. In this work, a bi- Received 11 December 2014 ventricular cardiac atlas was built from a unique data set, which consists of high resolution cardiac MR images Revised 24 July 2015 of 1000+ normal subjects. Based on the atlas, statistical methods were used to study the variation of cardiac Accepted 20 August 2015 shapes and the distribution of cardiac motion across the spatio-temporal domain. We have shown how statis- Available online 1 September 2015 tical parametric mapping (SPM) can be combined w