IgTCR基因重排原理及多样性.pptVIP

Chapter4The generation of lymphocyteantigen receptorsPrimary immunoglobulin gene rearrangementAntibody repertoire : 1011 in human - The total number of antibody specificities available to an individual Ig gene rearrangement in antibody producing cells - Southern blot analysis non lymphoid cell : V,C in the distant fragments mature B cell : V,C in the same fragments ? somatic recombination Figure 4.1 - V gene rearrangement Figure 4.2 V region of light chain : V gene segment (VL protein) (VL