转化生长因子β1促进生物稳定性聚氨酯支架表面软骨组织生成的中期报告.docxVIP

转化生长因子β1促进生物稳定性聚氨酯支架表面软骨组织生成的中期报告 摘要： 本研究旨在探讨转化生长因子β1（TGF-β1）对生物稳定性聚氨酯支架表面软骨组织生成的作用。实验采用大鼠关节软骨细胞种植于聚氨酯支架表面，分为对照组和实验组，在实验组中加入TGF-β1，观察软骨组织的生长变化。实验结果显示，TGF-β1可以显著促进软骨组织的生成，同时可以改善生物稳定性聚氨酯支架与软骨细胞的结合情况，提高支架的生物相容性。因此，TGF-β1在生物稳定性聚氨酯支架表面软骨组织工程中具有良好的应用前景。 关键词：生物稳定性聚氨酯支架；软骨组织工程；转化生长因子β1；生物相容性 Abstract： The aim of this study was to investigate the effect of transforming growth factor β1(TGF-β1) on the generation of cartilage tissue on the surface of biomedical polyurethane scaffold. The experiment used rat articular chondrocytes implanted on the surface of the polyurethane scaffold, and was divided into a control group and an experimental group. TGF-β1 was added to the experimental group to observe the growth changes of cartilage tissue. The results showed that TGF-β1 could significantly promote the generation of cartilage tissue, and improve the binding of biomedical polyurethane scaffold with chondrocytes, and improve the biocompatibility of the scaffold. Therefore, TGF-β1 has good application prospects in cartilage tissue engineering on the surface of biomedical polyurethane scaffolds. Keywords: Biomedical polyurethane scaffold; Cartilage tissue engineering; Transforming growth factor β1; Biocompatibility