抗生素作用的病理生理学Huntingintracellular-bacteria-with-ant课件.pptxVIP

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抗生素作用的病理生理学Huntingintracellular-bacteria-with-ant课件.pptx

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Paul M. Tulkens, MD, PhD Cellular and Molecular Pharmacology Unit Centre for Clinical Pharmacy Louvain Drug Research Institute Catholic University of Louvain, Brussels, Belgium Hunting intracellular bacteria with antibiotics 1st International and 12th Iranian Congress of Microbiology Karmanshah, Iran, 24 May 2011 1 But before that, where are you from ? Belgium The medical campus of the Université catholique de Louvain slides are available on www.facm.ucl.ac.be Lectures The Cellular and Molecular Pharmacology Group 1st International and 12th Iranian Congress of Microbiology Brussels Karmanshah, Iran, 24 May 2011 2 Intracellular infection: bacterial strategies Carryn et al. Infect Dis Clin North Am. 2003;17:615-34. 1st International and 12th Iranian Congress of Microbiology Karmanshah, Iran, 24 May 2011 3 Intracellular infection and recurrence/relapses: the case of S. aureus (as an example) 1st International and 12th Iranian Congress of Microbiology Karmanshah, Iran, 24 May 2011 4 Intracellular infection and recurrence/relapses: the case of S. aureus (as an example) Phagocytic and non phagocytic cells in mastitis Brouillette et al., Microb. Pathog. (2003) 35:159-68 1st International and 12th Iranian Congress of Microbiology Karmanshah, Iran, 24 May 2011 5 • Staphyloxanthin and intracellular survival • Activity of availailable antibiotics • What for the future ? Pharmacochemistry and Biology to your help ! A real need... 1st International and 12th Iranian Congress of Microbiology Karmanshah, Iran, 24 May 2011 6 Settting up the model … Seral et al. Antimicrob. Agents Chemother. 2003 47:2283-2292 1st International and 12th Iranian Congress of Microbiology Karmanshah, Iran, 24 May 2011 7 fibrinogen EbpS α5 β 1integrin Skin infections necrotizing pneumonia Food poisoning Scald skin syndrome impetigo Toxic shock syndrome S. aureus virulence factors nucleases proteases lipases collagenase hyalu