Lu 细胞因子 EN完整版.pptxVIP

Cytokines 鲁林荣 Linrong Lu ZJU Instiitute of Immunology Lu.Linrong@ /personne 课件与相关阅读 Cytokines are low-molecular weight regulatory proteins （ glycoproteins) secreted by white blood cells and various other cells in the body in response to a number of stimuli . These proteins mediate and regulate immune and inflammatory reactions . Definition Cytokines 1. General Properties of Cytokines 2. Functional Categories of cytokines 3. Cytokine receptors and signal transduction 4. Cytokines that mediate and regulate innate immunity 5. Cytokines that regulate Adaptive Immunity 6. Cytokines that stimulate Hematopoiesis 7. Cytokine related diseases 8. Therapeutic Use of cytokines 1. 1 Cytokine secretion is a brief, self-limited event ; 1.2 The actions of cytokines are often pleiotropic and redundant ; 1.3 Cytokines often influence the synthesis and actions of other cytokines ; 1. General Properties 1.4. Cytokine actions may be local and systemic ; 1.5. Cytokines initiate their actions by binding to specific membrane receptors on target cells ; 1.6. The cellular responses to most cytokines consist of changes in gene expression in target cells, resulting in the expression of new functions in the target cells 1. General Properties Cytokine secretion upon CpG treatment 1. Absent from un stimulated cells. 2. Rapid transcriptional activation with stimula 3. Can have post-translational control ; 4. Rapid secretion . 5. Short-lived transcripts and proteins. 6. Transcription ceases when stimulus abates. 1.1 Cytokine secretion is a brief, self-limited event ; IL2 secretion by CD4 T cells upon TCR engagement 1.2 The actions of cytokines are often pleiotropic and redundant One cytokine can target different target cells 1.2 The actions of cytokines are often pleiotropic and redundant Different cytokines can exert similar effect 1.3 Cytokines often influence the synthesis and actions of other cytokines ; Cytokines can work together or against each other 1.3