演示文稿布南色林受体作用临床数据受体与改善认知.pptVIP

**布南色林：强阻断D2、D3和5-HT2A受体的DSADSA：D2受体亲和力强于5-HT2A受体亲和力SDA：5-HT2A受体亲和力强于D2受体亲和力Ki(nM)RatioD2/5-HT2A分类D2D35-HT2AAtypicalantipsychotics阿立哌唑Aripiprazole0.741.08.70.085DSA布南色林Blonanserin0.140.490.810.17DSA喹硫平Quetiapine3106501202.6SDA哌罗匹隆Perospirone1.34.40.225.9SDA奥氮平Olanzapine17541.98.9SDA帕利哌酮Paliperidone4.07.50.2516SDA利培酮Risperidone3.3130.1621SDA齐拉西酮Ziprasidone9.77.50.3131SDA氯氮平Clozapine1503603.345SDAPsychiatryClinNeurosci.2015;69(5):243-58.本文档共23页；当前第1页；编辑于星期日\18点22分洛珊与D2受体有高度亲和力，

有效改善阳性症状精神分裂症患者中脑边缘多巴胺通路活动过度，导致阳性症状。使用D2受体