中山附属一医院病理科讲稿.pdf

DiseasesofDigestiveSystem

(2)

BingLiao

Dept.ofPathology,TheFirstAffiliated

HospitalofSunYaUniversity

2014-4-30

DiseasesofDigestiveSystem

•diseaseofthegastrointestinaltract

•diseaseoftheliver

•Theliveranditscompanionbiliarytreeand

gallbladderareconsideredtogetherbecause

oftheiranatomicproximity,theirinterrelated

functions,andtheoverlapfeaturesof

someofthediseasesthataffecttheseorgans.

Mostofthechapterisabouttheliver,because

ithasafargreaterroleinnormalphysiology

andisthesiteofawidevarietyofdiseases.

•Theliverhasenormousfunctionalreserve,

andregenerationoccursinallbutthemost

fulminantofhepaticdiseases.

•Thefunctionalreserveandthe

regenerativecapacityofthelivermaskto

someextenttheclinicalimpactofearly

liverdamage.However,withprogression

ofdiffusediseaseordisruptionofthe

circulationorbileflow,theconsequences

ofderangedliverfunctionelife-

threatening.

Lecture2.Diseaseoftheliver

•Viralhepatitis

•Alcoholicliverdisease

•Cirrhosis

•PrimaryCarcinomaoftheliver

Normalanatomyofliver

Averages1400-1600ginadult.

Grosslydividedintoleft,rightlobes.

Normalhistologyofliver

•hepaticlobules:

1-2mmmeter,hexagonal,centralveinin

middle

•portaltract:

portalvein,hepaticartery,bileduct,lymphtics,

nervesandconnectivetissue

limitingte:lineupofhepatocytessurroundingportal

tract

hepatocyticcords:onecellthickinadult,twocellsthick

innewborns(andinregeneratingliver).

Sinusoids:linedbydisc